Although the oral ethyl alcohol of foreign country has proven percentage with appropriate volume, the Kerow Company of Bangladesh although produced ethyl alcohol and named premium whisky, it does not provide percentage of ethyl alcohol or constant volume in their bottles. The oral ethanol is available at regulated registered bar and big hotels. The absolute ethanol is also out of reach and available only in chemical laboratory. Currently in Bangladesh fomepizole is not available and it is also expensive. That’s why fomepizole is chosen antidote although the superiority data is lacking. These include complex dosing, difficulties with maintaining therapeutic concentrations, the need for clinical and laboratory monitoring, and adverse effects. There are disadvantages associated with ethanol ingestions. The metabolic acidosis should be managed by giving intravenous sodium bi carbonate. Generation of toxic metabolite should be blocked by the administration of fomepizole or ethanol and formic acid metabolism should be enhanced by the administration of intravenous folinic acid.
There is then a latent period lasting approximately 12-24 hours following which an uncompensated metabolic acidosis develops and visual function becomes impaired, ranging from blurred vision and altered visual fields to complete blindness.
Methanol poisoning typically induces nausea, vomiting, abdominal pain, and mild central nervous system depression. In course of oxidation, formaldehyde and finally formic acid are formed which are highly toxic even as small amount as 10 ml can cause permanent blindness. When taken with ethyl alcohol, it is metabolized only after complete metabolisation of ethyl alcohol. It becomes highly toxic when it is mixed with ethyl alcohol as it is adulerated. Methylated spirit is very cheap and frequently available hence it is easily adulterated and used as country liquor. Methanol is methyl alcohol commonly used in many home chemicals, duplicating fluids, varnishes, stains, paint thinners and dyes.
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